Hydrogen-bonding patterns in trimethoprim tetrafluoroborate
نویسندگان
چکیده
منابع مشابه
Crystal engineering of analogous and homologous organic compounds: hydrogen bonding patterns in trimethoprim hydrogen phthalate and trimethoprim hydrogen adipate
BACKGROUND Trimethoprim [2,4-diamino-5-(3',4',5'-trimethoxybenzyl)pyrimidine] is an antifolate drug. It selectively inhibits the bacterial dihydrofolate reductase (DHFR) enzyme. RESULTS In the crystal structures of trimethoprim (TMP)-hydrogen phthalate (1) and trimethoprim-hydrogen adipate (2), one of the N atoms of the pyrimidine ring is protonated and it interacts with the deprotonated carb...
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In the hydrogen-bonding networks of 8-hydroxy-5-hydroxymethyl-3,6-dioxatricyclo[6.3.1.0(1.5)]dodecan-2-one and 5,7-bis(hydroxymethyl)-3,6-dioxatricyclo[5.3.1.0(1.5)]undecan-2-one, both C11H16O5, layers and double strands, respectively, lead to the formation of chains connected by hydroxy-to-hydroxy contacts, where the hydroxymethyl group, present in both structures, acts as a donor. The seconda...
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IN THE ASYMMETRIC UNIT OF THE TITLE SALT [SYSTEMATIC NAME: 2,4-diamino-5-(4-chloro-phen-yl)-6-ethyl-pyrimidin-1-ium pyri-dine-3-sulfonate], C(12)H(14)N(4)Cl(+)·C(5)H(4)NSO(3) (-), there are two independent pyrimethaminium cations and two 3-pyridine sulfonate anions. Each sulfonate group inter-acts with the corresponding protonated pyrimidine ring through two N-H⋯O hydrogen bonds, forming a cycl...
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The crystal and molecular structures of 4-ethyl-3,5-dimethylpyrrole-2-carbaldehyde, C10H15NO, (I), benzyl 3,5-dimethylpyrrole-2-carboxylate, C14H15NO2, (II), benzyl 4-acetyl-3,5-dimethylpyrrole-2-carboxylate, C16H17NO3, (III), dimethyl 3,5-dimethylpyrrole-2,4-dicarboxylate, C10H13NO4, (IV), 4-ethyl-3,5-dimethyl-2-(p-tosylacetyl)pyrrole, C17H21NO3S, (V), and ethyl 4-(2-ethoxycarbonyl-2-hydroxyac...
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ژورنال
عنوان ژورنال: Acta Crystallographica Section E Structure Reports Online
سال: 2005
ISSN: 1600-5368
DOI: 10.1107/s1600536805036615